Shane (Vincent Gallo) and his new wife June (Tricia Vessey) are newlyweds honeymooning in Paris. Although happy, their relationship becomes strained when Shane secretly visits the medical clinic where he was once involved in experimental research on the human libido.

Before long, the effect of this research becomes terrifyingly obvious, and Shane seeks self-exile in a desperate effort to find a cure. All the while, Core (Beatrice Dalle), a Parisian woman, preys upon the men she lures with the promise of sexual gratification.